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NPS-2143 hydrochloride
CAS No. 324523-20-8
NPS-2143 hydrochloride( NPS2143 hydrochloride | NPS 2143 hydrochloride )
Catalog No. M14052 CAS No. 324523-20-8
A potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 115 | In Stock |
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| 25MG | 203 | In Stock |
|
| 50MG | 320 | In Stock |
|
| 100MG | 475 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNPS-2143 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors.
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DescriptionA potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors; stimulates parathyroid hormone (PTH ) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo; also inhibits lipopolysaccharide-induced pulmonary inflammation.Osteoporosis Discontinued.
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In Vitro——
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In Vivo——
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SynonymsNPS2143 hydrochloride | NPS 2143 hydrochloride
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PathwayGPCR/G Protein
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TargetCaSR
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RecptorCaSR
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Research AreaMetabolic Disease
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IndicationOsteoporosis
Chemical Information
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CAS Number324523-20-8
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Formula Weight445.3814
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Molecular FormulaC24H26Cl2N2O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl
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Chemical Name(R)-2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gowen M, et al. J Clin Invest. 2000 Jun;105(11):1595-604.
2. Nemeth EF, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.
3. Lee JW, et al. Mol Immunol. 2017 Oct;90:150-157.
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